Why Can’t I Lose Weight No Matter What I Do? Proven Solutions from an Obesity Medicine Expert

By Dr. Crystal Broussard

Quick Insights

“What is ‘why can’t I lose weight no matter what I do’?” It refers to persistent weight loss struggle despite ongoing effort, often linked to underlying medical, hormonal, or lifestyle factors, as supported by medical research and clinical experience.

Key Takeaways

• Over half of lost weight is regained within two years; 80% is regained by five years, according to clinical research.
• Medical issues like hormone imbalances, certain medications, and genetics can hinder effective weight loss for many adults.
• Weight loss plateaus affect approximately 85% of dieters, representing a major source of frustration and confusion.
• Working over 40 hours per week increases obesity risk by 40%, making stress and routine significant contributors to stalled progress.

Why It Matters

Understanding why you can’t lose weight no matter what you do can relieve self-blame and emotional stress, paving the way for real solutions. Physician-guided answers turn frustration into hope, helping restore confidence, energy, and lasting control over your health journey.

Introduction

As a board-certified family physician and aesthetic expert, I’ve been on the front lines of the “why can’t I lose weight no matter what I do” struggle—both in my own life and for thousands of patients.

This phrase describes the overwhelming frustration of making good choices day after day, yet watching the scale refuse to budge or, worse, backtrack. It’s not just about willpower; real medical, hormonal, and metabolic factors can silently work against even the most determined efforts.

Decades of research confirm that more than half of lost weight returns within two years and 80% is regained by the five-year mark, highlighting just how common—and disheartening—these setbacks are for women everywhere (weight regain statistics). That’s why I founded Harmony Aesthetics Spa—where personalized, physician-led support meets the science of metabolism, hormones, lifestyle, and emotional shifts.

You are not alone—and there is a medically sound path forward, grounded in compassion and the real answers your body deserves.

Understanding Medical Factors Behind “Why Can’t I Lose Weight No Matter What I Do”

When you’re asking, “why can’t I lose weight no matter what I do,” it’s important to know that real medical factors can make weight loss feel impossible. In my practice, I’ve seen countless women who eat well, move more, and still feel stuck. It’s not just about willpower.

What are medical reasons for not losing weight?

Common medical reasons include:

• Thyroid disorders (like hypothyroidism—when your thyroid is underactive)
• Polycystic ovary syndrome (PCOS)—a hormone imbalance common in women
• Insulin resistance—when your body struggles to use insulin properly
• Genetic factors—family history can play a big role
• Medications—certain antidepressants, steroids, and birth control can cause weight gain

Metabolism, or how your body burns calories, can slow down as you lose weight. This “metabolic adaptation” is your body’s way of protecting itself, but it can make further weight loss much harder. Research shows that more than half of lost weight is regained within two years, and 80% by five years, which is incredibly frustrating for so many women weight regain statistics.

Medications are another hidden barrier. Drugs for depression, mood, inflammation, and even birth control can all slow your progress. I always review my patients’ medication lists to spot these roadblocks and to provide alternative strategies when possible.

If you’re thinking, “I can’t lose weight no matter what I do female,” you’re not alone. Medical causes are common and deserve real answers—not blame. As a physician, I use a full evaluation to separate medical from lifestyle barriers, so you get a plan that actually fits your body’s needs obesity causes and management.

Most common medical reasons for not losing weight:

• Underactive thyroid (hypothyroidism)
• PCOS (polycystic ovary syndrome)
• Insulin resistance or prediabetes
• Certain medications (antidepressants, steroids, birth control)
• Genetics/family history

If you’ve tried everything and still struggle, a physician-led assessment is crucial. I’ve helped many women finally get answers after years of frustration.

How Common Medications and Hormones Affect “Why Can’t I Lose Weight No Matter What I Do”

Medications and hormones can quietly sabotage your weight loss journey. Antidepressants, antipsychotics, corticosteroids, and some birth control pills are known to cause weight gain or make it harder to lose weight. Hormonal imbalances—like low thyroid, menopause, or PCOS—can slow metabolism and increase cravings.

• Drug classes that impact weight:
  • Antidepressants (SSRIs, tricyclics)
  • Antipsychotics
  • Corticosteroids
  • Hormonal contraceptives
• Hormonal conditions:
  • Hypothyroidism (low thyroid hormone)
  • PCOS (hormone imbalance in women)
  • Menopause (natural hormone decline)

Never stop a prescribed medication without talking to your physician. At Harmony Aesthetics Spa, I use a detailed review to uncover these hidden barriers. For some, GLP-1 medical weight loss program (injectable treatments that help regulate appetite) can be a game-changer when lifestyle changes alone aren’t enough metabolic adaptation research.

When to Seek Medical Attention

See a physician if you experience:

• Sudden, unexplained weight gain or loss
• Persistent fatigue, hair loss, or irregular periods
• No progress despite consistent healthy habits

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Evidence-Based Solutions to “Why Can’t I Lose Weight No Matter What I Do” with Physician-Led Care

If you’re stuck asking, “why can’t I lose weight no matter what I do,” it’s time to shift from blame to solutions. From my perspective as a family medicine physician with advanced training in obesity medicine, I believe in a step-by-step, physician-led approach that addresses your unique needs—not just generic advice.

First, I start with a personalized plan that covers nutrition, activity, and emotional support. We look at your daily habits, stress, and sleep. Ongoing medical oversight is key—my patients get regular check-ins, so we can adjust your plan as your body changes.

For some, medication-based options like GLP-1s (semaglutide, tirzepatide) are appropriate. These injectable medications help regulate appetite and support weight loss when lifestyle changes alone aren’t enough. I only recommend them after a thorough evaluation, and I monitor for side effects and progress physician-guided obesity medications.

Plateaus are normal, but they don’t have to be permanent. I help you overcome plateaus by switching up routines, adding new activities, and using behavioral strategies like habit tracking and stress management. Weekly accountability—whether in-person, virtual, or by text—keeps you motivated and supported.

My approach is always consultative and non-judgmental. I know how emotional this journey can be, and I’m here to help you feel safe and heard. At Harmony Aesthetics Spa, you’re never just a number—you’re a partner in your own care behavioral and medical interventions.

How can you start overcoming weight loss plateaus?

• Track your food and activity honestly
• Change up your exercise routine
• Prioritize sleep and stress management
• Consider medical evaluation for hidden barriers
• Stay consistent—progress is rarely linear

I’ve seen women break through years-long plateaus with the right support and a plan that fits their real life. Hybrid care—combining in-person visits with virtual check-ins—makes it easier to stay on track, no matter how busy you are.

Medication-Based and Lifestyle Interventions for “Why Can’t I Lose Weight No Matter What I Do”

Not everyone needs medication, but for some, it’s the missing piece. Based on treating hundreds of patients battling hormonal weight gain and skin issues, I’ve found that treating root causes like insulin resistance and hormone imbalance unlocks better, lasting results. I use semaglutide and tirzepatide injections when lifestyle changes alone aren’t enough, especially for those with metabolic or hormonal resistance. These medications are safe when monitored by a physician and can help you finally see results role of GLP-1 medications.

For others, a lifestyle-only approach works best. My care pathway includes:

• Weekly monitoring and support
• Tailored nutrition and activity plans
• Emotional and stress management tools

Top weight loss tips:

• Eat regular, balanced meals—don’t skip!
• Move your body daily, even if it’s just a walk
• Track your habits to spot patterns
• Celebrate small wins

Managing stress and emotions is just as important as diet and exercise. I encourage you to reach out for support—no shame, no blame, just real solutions behavioral and medical interventions.

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Overcoming Plateaus and Taking Control: Restoring Hope When “Why Can’t I Lose Weight No Matter What I Do”

A weight loss plateau is when your progress stalls, even though you’re still following your plan. About 85% of dieters hit a plateau at some point, and it’s one of the most common reasons people feel defeated definition and management of plateaus.

What is a weight loss plateau?

A weight loss plateau happens when your body adapts to your current habits, causing your weight to stop changing despite continued effort.

Plateaus are not your fault. They’re a normal part of the journey, caused by your body’s natural adaptation, changes in metabolism, and sometimes by stress or environmental factors. Long work hours, high stress, and lack of sleep can all make it harder to lose weight socioeconomic and lifestyle impact on obesity.

In my practice, I help women break through plateaus by reassessing their routines, adding variety to workouts, and sometimes adjusting their nutrition or medications. Consistent support and medical oversight make a huge difference.

If you’re feeling stuck, remember: plateaus are temporary. With the right plan and support, you can move forward again.

When to Seek Medical Attention for Stalled Weight Loss Efforts

See a physician if you notice:

• Sudden weight changes without explanation
• Persistent symptoms (fatigue, mood changes, irregular periods)
• No progress after months of healthy habits

Don’t blame yourself—reach out for help. At Harmony Aesthetics Spa, I offer both urgent and routine assessments to keep your health and safety first.

Our Approach to Patient Care

When it comes to the question, “why can’t I lose weight no matter what I do,” I know firsthand how overwhelming and isolating this struggle can feel. As a board-certified physician in family medicine with specialized training in Obesity Medicine, I’ve dedicated my practice to helping women uncover the real reasons behind stalled weight loss—without blame or shame.

At Harmony Aesthetics Spa, my approach is rooted in evidence-based medicine and genuine partnership. I believe every patient deserves a thorough evaluation that looks beyond the surface, considering medical, hormonal, and lifestyle factors that are often overlooked in standard care. My protocols are designed to be both compassionate and rigorous, ensuring that each plan is tailored to your unique needs and medical history.

I stay current with the latest research and treatment options, including advanced therapies for hormone imbalance and metabolic resistance. My goal is to empower you with answers, support, and a clear path forward—so you can finally break free from the cycle of frustration and regain confidence in your health journey.

If you’re ready for a physician-led, personalized approach that truly addresses your weight loss challenges, I invite you to reach out and take the next step toward lasting change.

Weight Loss Solutions for Women Across the Nation

Struggling with weight loss is a challenge faced by women in every corner of the country, not just in one city or region. The factors that make weight loss difficult—like hormonal changes, long work hours, and stress—are common across the United States, affecting women from all walks of life.

At Harmony Aesthetics Spa, I offer a national approach to care that recognizes the diversity of experiences and backgrounds among women seeking real solutions. Whether you’re managing a busy career, balancing family life, or dealing with unique health concerns, my physician-led programs are designed to fit your lifestyle and needs, no matter where you live.

By providing both in-person and virtual support, I make it easier for women nationwide to access expert guidance and ongoing accountability. My commitment is to deliver the same high standard of care and compassion to every patient, regardless of location.

If you’re ready to move past frustration and discover a plan that works for your body, book your free consultation today. Let’s start your personalized wellness journey—wherever you are in the nation.

Conclusion

To summarize, if you’re asking, “why can’t I lose weight no matter what I do,” know that real medical, hormonal, and lifestyle factors often stand in the way—this is not your fault. As a physician specializing in family medicine and obesity medicine, I’ve seen firsthand how a personalized, physician-led approach can help you break through plateaus and regain confidence. Sustainable weight loss is possible when you have the right support, medical guidance, and a plan tailored to your unique needs. My care model is rooted in compassion, dignity, and evidence-based solutions, helping you move from frustration to real progress.

If you’re ready to take back control of your health and body, I invite you to book your free consultation today to start your personalized wellness journey. Text us to ask questions or schedule a visit—we’re here to help. For the best results, always seek medical advice and aim for steady, sustainable changes, as recommended by leading healthcare professionals.

This article is for informational purposes only and does not replace medical advice from your physician.

Frequently Asked Questions

Why can’t I lose weight no matter what I do?

Many people struggle with weight loss due to hidden medical issues like hormone imbalances, certain medications, or genetics. In my practice, I see that even with healthy habits, these factors can slow progress. A physician-guided evaluation helps uncover the real reasons and creates a plan that actually works for your body.

Where can I find physician-led weight loss support if I don’t live nearby?

You don’t have to be local to get help. I offer both in-person visits at Harmony Aesthetics Spa and virtual consultations nationwide. This way, you can access personalized, physician-led weight loss support and ongoing accountability, no matter where you live.

What should I do if I’ve tried every diet and still can’t lose weight?

If you’ve tried multiple diets and exercise plans without success, it’s time for a medical assessment. In my experience, many patients benefit from a full review of their health, medications, and lifestyle. Sometimes, prescription options or advanced therapies are needed—always under physician supervision for safety and best results.

About the Author

Dr. Crystal Broussard, MD, is a board-certified family physician and a Fellow of the American Board of Obesity Medicine. As the founder of Harmony Aesthetics Spa in North Houston, Dr. Broussard blends medical expertise with personal passion, having lost over 100 pounds herself following the birth of her first child. She specializes in physician-supervised weight loss and aesthetic medicine, helping patients achieve long-term wellness and confidence. A nationally recognized expert in bariatric care and a featured contributor to programs like The PINK Method, Dr. Broussard is known for her warm, relatable approach and her commitment to empowering others through evidence-based treatments and compassionate care.